Glibenclamide 5 Mg
Glibenclamide is available in the market as Daonil, Semi daonil, Glynase, Micronase, Diabeta and Euglucon. It is available in combination with Metformin as Glucovance, Glibomet and Glibenclamide Metformin.
Glibenclamide is used in the treatment of type II diabetes which is also called adult onset diabetes mellitus. In this condition he patient is able to produce insulin but is of decreased quantity or the tissue response to the insulin is impaired.
Glibenclamide, being a sulphonylurea drug inhibits the ATP- sensitive potassium channels in the pancreatic beta cells thereby causing cell membrane depolarization. This opens up the voltage dependent calcium channels and results in an increase in the intracellular calcium. The increased intracellular calcium in the pancreatic beta cells result in the stimulation of insulin release.
The major side effects of Glibenclamide are hypoglycemia, allergic reactions, palpitation, nausea, vomiting, headache, weight gain, convulsions, loss of appetite, joint pain, frequent urination, tremors, facial puffiness, double vision, heartburn, sleep disturbances, diarrhea, constipation, and some blood disorders.
The drugs which increase the blood level while using Glibenclamide are corticosteroids, diuretics, oral contraceptives, chlorpromazine and rifampicin. The drugs which further reduce the blood sugar level while taking along with Glibenclamide are aspirin, Non steroidal anti- inflammatory drugs, sulphonamide antibiotics, beta blockers, cotrimoxazole, warfarin, antifungal drugs, testosterone, phenylbutazone, clofibrate and monoamine oxidase inhibitors which are used as antidepressants.
Glibenclamide is contra indicated in pregnancy, during lactation, surgeries, stressful conditions, type I or juvenile diabetes, liver diseases, kidney diseases, diabetic ketoacidosis and acidosis.
Glibenclamide 5 mg is generally given as an initial dose once daily to check for patient compliance. It is then gradually increased up to 15 mg once or twice daily depending upon the patient need.